Mouse Anti-Human SSEA-3 Antibody (S-3079)

SSEA-3 (Stage-Specific Embryonic Antigen-3) is a glycolipid surface antigen originally named for its specific expression during particular stages of mammalian embryonic development, and it is now widely used as a key marker for identifying the pluripotency of human embryonic stem cells and germ cells. In adult tissues, SSEA-3 is naturally present in the skin and bone marrow, serving as the core surface marker for "Muse cells" (Multilineage-differentiating Stress-Enduring cells); these cells possess tri-lineage differentiation potential without requiring genetic reprogramming, demonstrating immense promise in tissue repair and regenerative medicine. Furthermore, SSEA-3 holds significant pathological relevance, as its aberrant overexpression in certain malignancies (such as breast cancer) and cancer cell lines suggests a potential role in tumorigenesis and progression.