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宿主来源
Mouse抗原名称
XCR1分子别名
Chemokine XC receptor 1; Lymphotactin receptor; SCM1 receptor; XC chemokine receptor 1; mXCR1; Ccxcr1; Xcr1细胞定位
Cell membraneAccession
Q9R0M1克隆号
S-R601抗体类型
Mouse mAb抗体同种型
IgG2b,k反应种属 ?
Ms阳性样本
collagenase-digested C57BL/6 mouse splenocytes纯化方式
Protein A浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM Ms
XCR1 is a conserved, 37-kDa, seven-transmembrane, G-protein-coupled receptor selectively expressed on CD8α⁺ and CD103⁺ conventional dendritic cells; its only ligand, XCL1, is secreted by activated CD8⁺ T and NK cells to form a feed-forward loop that efficiently recruits antigen-bearing dendritic cells into draining lymph nodes, licenses cross-presentation, and amplifies cytotoxic immune responses against viruses and tumors, while genetic or antibody blockade of XCR1 impairs viral clearance, vaccine efficacy, and checkpoint-blockade-mediated anti-tumor immunity.
流式分析
Flow cytometric analysis of collagenase-digested C57BL/6 mouse splenocytes labelling Mouse XCR1 antibody at 1/100 dilution (2 μg) / (Right panel) compared with a Mouse IgG2b, κ Isotype Control / (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD8 - Alexa Fluor® 647 Antibody separately.
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