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宿主来源
Rat抗原名称
MERTK分子别名
Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; Mer; Mertk细胞定位
Cell membraneAccession
Q60805克隆号
S-R603抗体类型
Rat mAb抗体同种型
IgG2a,k反应种属 ?
Ms阳性样本
BALB/c mouse peritoneal exudates cells纯化方式
Protein G浓度
0.5 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1μg per million cells in 100μl volume Ms
MERTK, also known as MER proto-oncogene tyrosine kinase, is a type I receptor tyrosine kinase and a member of the TAM (TYRO3, AXL, and MERTK) family. It plays crucial roles in various physiological processes, including cell survival, migration, differentiation, and the phagocytosis of apoptotic cells. MERTK is activated by binding to ligands such as GAS6 and PROS1, which triggers autophosphorylation and downstream signaling through pathways like PI3K/AKT, MAPK, and STAT. This receptor is highly expressed in immune cells like macrophages and dendritic cells, and its activation promotes an anti-inflammatory M2 phenotype in macrophages. In the retina, MERTK is essential for the phagocytosis of rod outer segment fragments by the retinal pigment epithelium. Abnormal expression of MERTK has been linked to several diseases, including retinitis pigmentosa and various cancers, making it a potential therapeutic target.
流式分析
Flow cytometric analysis of mouse MERTK expression on BALB/c mouse peritoneal exudates cells. BALB/c mouse peritoneal exudates cells were stained with Brilliant Violet 421™ Rat Anti-Mouse F4/80 Antibody and either Biotin Rat IgG2a, κ Isotype Control (left panel) or SDT Biotin Rat Anti-Mouse MERTK Antibody (right panel) at 2μl/test followed by Sav-PE. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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