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宿主来源
Rat抗原名称
CD193分子别名
Probable C-C chemokine receptor type 3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR3; Macrophage inflammatory protein 1-alpha receptor-like 2 (MIP-1 alpha RL2); Cmkbr1l2; Cmkbr3细胞定位
Cell membraneAccession
P51678克隆号
S-R699抗体类型
Rat mAb抗体同种型
IgG2a,k反应种属 ?
Ms阳性样本
Fresh C57BL/6 mouse splenocytes纯化方式
Protein G浓度
0.2 mg/ml标记
APC性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 0.25μg per million cells in 100μl volume Ms
CD193, also known as C-C motif chemokine receptor 3 (CCR3), is a member of the G protein-coupled receptor (GPCR) family, characterized by its seven-transmembrane structure. It is a high-affinity receptor for various chemokines, including eotaxin-1 (CCL11), eotaxin-2 (CCL24), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). CD193 is highly expressed on eosinophils, basophils, and airway epithelial cells, and is also detected in CD4+ T cells, mast cells, monocytes, platelets, and CD34+ hematopoietic progenitor cells. This receptor plays a crucial role in mediating the migration and activation of eosinophils and other inflammatory cells, contributing to allergic responses and inflammatory processes in conditions such as asthma and allergic rhinitis. Additionally, CD193 has been identified as a co-receptor for HIV-1 entry into cells.
流式分析
Flow cytometric analysis of mouse CD193 expression on fresh C57BL/6 mouse splenocytes. Fresh C57BL/6 mouse splenocytes were stained with Pacific Blue™ Rat Anti-Mouse Ly6G/Ly6C Antibody and either APC Rat IgG2a, κ Isotype Control (left panel) or SDT APC Rat Anti-Mouse CD193 Antibody (right panel) at 1.25 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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