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Anti-Human PDGFRα Monoclonal Antibody (Olaratumab)

Platelet-derived growth factor receptor alpha,PDGF-R-alpha,PDGFR-alpha,Alpha platelet-derived growth factor receptor,Alpha-type platelet-derived growth factor receptor,CD140 antigen-like family member A,CD140a antigen,Platelet-derived growth factor alpha receptor,Platelet-derived growth factor receptor 2 (PDGFR-2),CD140a,PDGFR2,RHEPDGFRA,PDGFRA

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货号 S0B7146
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Human

  • 抗原名称

    PDGFRα

  • 分子别名

    Platelet-derived growth factor receptor alpha; PDGF-R-alpha; PDGFR-alpha; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2 (PDGFR-2); CD140a; PDGFR2; RHEPDGFRA; PDGFRA

  • 细胞定位

    Cell membrane

  • Accession

    P16234

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG1,k

  • 反应种属 ?

    Hu

  • 纯化方式

    Protein A

  • 浓度

    5 mg/ml

  • 内毒素含量

    <1EU/mg

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, containing no preservative

  • 储存条件

    2 to 8 °C for 2 weeks under sterile conditions;
    -20 °C for 3 months under sterile conditions;
    -80 °C for 24 months under sterile conditions.
    Please avoid repeated freeze-thaw cycles.

  • 应用

    Blocking of Mesothelin signaling Functional assays

    WB

  • 稀释度

    应用 稀释度 推荐种属
    WB 1:1000 Hu
背景介绍

  • CD140a (also called platelet-derived growth factor receptor-alpha, PDGFR-α) is a 170-kDa glycosylated cell-surface receptor tyrosine kinase encoded by the PDGFRA gene, featuring an extracellular ligand-binding region with five immunoglobulin-like domains, a single transmembrane segment and an intracellular split tyrosine-kinase domain; upon binding PDGF-AA, -AB or -BB it forms homo- or heterodimers, triggers downstream signalling cascades that drive proliferation, migration and differentiation of mesenchymal and glial cells, and is indispensable for embryogenesis of kidney, testis and other organs, wound healing and maintenance of hematologic tissues, while PDGFRA mutations or amplifications are linked to clonal hypereosinophilic neoplasms, gastrointestinal stromal tumours, gliomas and hepatocellular carcinoma, making CD140a a potential therapeutic target in these cancers .

  • 免疫印迹


    • WB result of Anti-Human PDGFRα Monoclonal Antibody (Olaratumab)
      Primary antibody: Anti-Human PDGFRα Monoclonal Antibody (Olaratumab) at 1/1000 dilution
      Lane 1: PDGF R alpha/PDGFRA His Tag Protein, Human lysate 1 µg
      Secondary antibody: Goat Anti-Human IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 80 kDa
      Observed MW: 80 kDa

  • ELISA

    • Immobilized PDGF R alpha/PDGFRA His Tag Protein, Human (UA010720) can bind Olaratumab. The EC50 for this effect is 2.717 ng/mL.

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