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Anti-Human/Cynomolgus Monkey 4-1BB Monoclonal Antibody (Utomilumab)

Tumor necrosis factor receptor superfamily member 9,4-1BB ligand receptor,CDw137,T-cell antigen 4-1BB homolog,T-cell antigen ILA,CD137,ILA,TNFRSF9

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货号 S0B7143
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Human

  • 抗原名称

    4-1BB

  • 分子别名

    Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CD137; ILA; TNFRSF9

  • 细胞定位

    Cell membrane

  • Accession

    Q07011

  • 抗体类型

    Recombinant mAb

  • 反应种属 ?

    CyMk, Hu

  • 纯化方式

    Protein A

  • 浓度

    5 mg/ml

  • 内毒素含量

    <1EU/mg

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, containing no preservative

  • 储存条件

    2 to 8 °C for 2 weeks under sterile conditions;
    -20 °C for 3 months under sterile conditions;
    -80 °C for 24 months under sterile conditions.
    Please avoid repeated freeze-thaw cycles.

  • 应用

    Blocking of 4-1BB signaling Functional assays

    ELISA

背景介绍

  • CD137, also known as 4-1BB, is a co-stimulatory molecule expressed on the surface of activated T cells and natural killer cells. It plays a crucial role in enhancing the immune response by providing additional signals that promote T cell proliferation, survival, and cytokine production. CD137 is a member of the tumor necrosis factor receptor superfamily and its ligand, CD137L, is primarily found on antigen-presenting cells. The interaction between CD137 and CD137L helps to sustain the activation of T cells and supports the development of long-lasting immune responses, making it an important target for immunotherapy in cancer treatment and other diseases where modulation of the immune system is beneficial.

  • ELISA

    • Immobilized 4-1BB/TNFRSF9 His Tag Protein, Human (UA010796) can bind Utomilumab. The EC50 for this effect is 4.384 ng/mL.

    • Immobilized 4-1BB/TNFRSF9 His Tag Protein, Cynomolgus (UA010803) can bind Utomilumab. The EC50 for this effect is 5.520 ng/mL.

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