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Anti-Human FAP Monoclonal Antibody (Sibrotuzumab)

Prolyl endopeptidase FAP,170 kDa melanoma membrane-bound gelatinase,Dipeptidyl peptidase FAP,Fibroblast activation protein alpha (FAPalpha),Gelatine degradation protease FAP,Integral membrane serine protease

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货号 S0B7129
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Human

  • 抗原名称

    FAP

  • 分子别名

    Prolyl endopeptidase FAP; 170 kDa melanoma membrane-bound gelatinase; Dipeptidyl peptidase FAP; Fibroblast activation protein alpha (FAPalpha); Gelatine degradation protease FAP; Integral membrane serine protease

  • 细胞定位

    Cell membrane

  • Accession

    Q12884

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    Human IgG1

  • 反应种属 ?

    Hu

  • 纯化方式

    Protein A

  • 浓度

    5 mg/ml

  • 纯度

    >95% (Determined by SDS-PAGE)

  • 内毒素含量

    <1EU/mg

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, containing no preservative

  • 储存条件

    2 to 8 °C for 2 weeks under sterile conditions;
    -20 °C for 3 months under sterile conditions;
    -80 °C for 24 months under sterile conditions.
    Please avoid repeated freeze-thaw cycles.

  • 稀释度

    应用 稀释度 推荐种属
    WB 1:1000 Hu
背景介绍

  • Fibroblast Activation Protein (FAP) is a 97-kDa type-II transmembrane serine protease that is virtually absent from healthy adult tissues but becomes highly and persistently up-regulated on activated fibroblasts during wound healing, fibrosis, arthritis, atherosclerosis and in the stroma of over 90 % of epithelial cancers, where its unique endopeptidase (Gly-Pro-X) and dipeptidyl-peptidase activities drive extracellular-matrix remodelling, immune evasion, M2 macrophage polarization and tumour-cell proliferation, migration and invasion via signalling axes such as ITGB1/PI3K/AKT and interactions with fibronectin, collagen and immune-checkpoint ligands, making it a powerful prognostic biomarker and an attractive therapeutic target across multiple malignancies and fibrotic diseases.

  • 免疫印迹

    • WB result of Anti-Human FAP Monoclonal Antibody (Sibrotuzumab)
      Primary antibody: Anti-Human FAP Monoclonal Antibody (Sibrotuzumab) at 1/1000 dilution
      Lane 1: FAP His Tag Protein, Human lysate 1 µg
      Secondary antibody: Goat Anti-Human IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 88 kDa
      Observed MW: 88 kDa

  • ELISA

    • Immobilized FAP His Tag Protein, Human (UA010165) can bind Sibrotuzumab. The EC50 for this effect is 5.738 ng/mL.

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