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Human抗原名称
CD19分子别名
B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12细胞定位
Cell membraneAccession
P15391抗体类型
Recombinant mAb抗体同种型
Human IgG1反应种属 ?
Hu纯化方式
Protein A浓度
5 mg/ml纯度
>95% (Determined by SDS-PAGE)内毒素含量
<1EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, containing no preservative
储存条件
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.稀释度
应用 稀释度 推荐种属 WB 1:1000 Hu
CD19, also known as B-lymphocyte antigen CD19 or B-Lymphocyte Surface Antigen B4, is a 95 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily and is encoded by the CD19 gene. It is primarily expressed on all B lineage cells, from early pro-B cells to plasma cells, and plays a crucial role in B cell development, activation, and signaling. As a co-receptor, CD19 enhances signaling through the B cell receptor (BCR) complex, lowering the threshold for B cell activation and promoting B cell proliferation and differentiation. It forms a complex with CD21, CD81, and other proteins, which helps in the recognition of antigens tagged with complement and amplifies BCR signaling. CD19 is also a biomarker for B cell-related diseases and a target for immunotherapies, including monoclonal antibodies and CAR-T cell therapies, due to its consistent expression on B cells and B cell malignancies.
免疫印迹
WB result of Anti-Human CD19 Monoclonal Antibody (Tafasitamab)
Primary antibody: Anti-Human CD19 Monoclonal Antibody (Tafasitamab) at 1/1000 dilution
Lane 1: CD19 His Tag Protein, Human lysate 1 µg
Lane 2: CD19 His Tag Protein, Cynomolgus/Rhesus macaque lysate 1 µg
Secondary antibody: Goat Anti-Human IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 41 kDa
Observed MW: 41 kDa
ELISA
Immobilized CD19 His Tag Protein, Human (UA011126) can bind Tafasitamab. The EC50 for this effect is 4.002 ng/mL.
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