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Human抗原名称
CSF1R分子别名
Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor (CSF-1-R; CSF-1R; M-CSF-R); Proto-oncogene c-Fms; FMS; CD115细胞定位
Cell membraneAccession
P07333克隆号
S-5175抗体类型
Recombinant mAb抗体同种型
Human IgG1反应种属 ?
Hu纯化方式
Protein A浓度
5 mg/ml纯度
>95% (Determined by SDS-PAGE)内毒素含量
<1EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, containing no preservative
储存条件
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
CSE1R is a 972-amino-acid cell-surface glycoprotein encoded by the CSF1R gene (c-FMS proto-oncogene) that belongs to the type III receptor tyrosine kinase family; it serves as a receptor for the cytokines CSF-1 and IL-34, and is highly expressed on monocyte-lineage cells and osteoclasts, mediating their survival, proliferation, differentiation, and motility through ligand-induced oligomerization and transphosphorylation, with mutations linked to myeloid malignancies and increased expression observed in Alzheimer’s disease microglia and breast carcinogenesis .
免疫印迹
WB result of Anti-CSF1R Monoclonal Antibody (Emactuzumab)
Primary antibody: Anti-CSF1R Monoclonal Antibody (Emactuzumab) at 1/1000 dilution
Lane 1: M-CSFR His Tag Protein, Human 1ug
Secondary antibody: Goat Anti- Human IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 108 kDa
Observed MW: 75-100 kDa
ELISA
Immobilized M-CSFR His Tag Protein Human(UA010208) can bind Emactuzumab. The EC50 for this effect is 5.293 ng/mL.
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