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Anti-Human CD326 (EpCAM) Monclonal Antibody (Edrecolomab)

Epithelial cell adhesion molecule,Ep-CAM,Adenocarcinoma-associated antigen,Cell surface glycoprotein Trop-1,Epithelial cell surface antigen,Epithelial glycoprotein (EGP),Epithelial glycoprotein 314 (EGP314,hEGP314),GA733-2,M1S2,M4S1,MIC18,TACSTD1,TROP1,EPCAM

价格 ￥1,500.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B7106
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Mouse

  • 抗原名称

    EpCAM

  • 分子别名

    Epithelial cell adhesion molecule; Ep-CAM; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein (EGP); Epithelial glycoprotein 314 (EGP314; hEGP314); GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1; EPCAM

  • 细胞定位

    Cell membrane

  • Accession

    P16422

  • 克隆号

    S-4670

  • 抗体类型

    Mouse mAb

  • 抗体同种型

    IgG2a,k

  • 反应种属 ?

    Hu

  • 阳性样本

    HT29

  • 纯化方式

    Protein A

  • 浓度

    5 mg/ml

  • 内毒素含量

    <1EU/mg

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, containing no preservative

  • 储存条件

    2 to 8 °C for 2 weeks under sterile conditions;
    -20 °C for 3 months under sterile conditions;
    -80 °C for 24 months under sterile conditions.
    Please avoid repeated freeze-thaw cycles.

  • 应用

    Blocking of CD326 signaling Functional assays

  • 稀释度

    应用 稀释度 推荐种属
    FCM 1:1000 Hu
背景介绍

  • EpCAM (epithelial cell adhesion molecule, CD326) is a 35–40 kDa type-I transmembrane glycoprotein expressed on most epithelia, where it first assembles into cis-dimers that further cluster into tetramers to support homotypic cell–cell contacts, and then—through sequential proteolytic cleavage—releases its intracellular domain (EpICD) that partners with β-catenin, FHL2 and LEF1 to enter the nucleus and drive Wnt-dependent transcription of genes controlling proliferation, stemness and epithelial-to-mesenchymal transition, thereby functioning not merely as an adhesion molecule but as a dynamic signaling hub that is highly up-regulated in most carcinomas, marks circulating tumor and cancer stem cells, and serves as both a prognostic biomarker and a therapeutic target while mutations that truncate or mis-localize the protein underlie the severe congenital diarrhea disorder tufting enteropathy.

  • 流式分析

    • Flow cytometric analysis of HeLa (Human cervix adenocarcinoma epithelial cell, left) / HT29 (Human colorectal adenocarcinoma epithelial cell, right) labeled with CD326 antibody at 1/1000 dilution (0.5 μg) / (red) compared with a Mouse IgG2a,κ (black) Isotype Control and an unlabelled control (cells without incubation with primary antibody and secondary antibody) (blue). Goat Anti - Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Total viable cells, as determined by Fixable Viability Dye 583 (S0B88803), were used for analysis. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
      Negative control: HeLa

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