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Anti-Human Nectin-4 Monoclonal Antibody (Enfortumab)

Ig superfamily receptor LNIR,Nectin cell adhesion molecule 4Imported,Poliovirus receptor-related protein 4,LNIR,PRR4,PVRL4,NECTIN4

价格 ￥2,000.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B7089
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Human

  • 抗原名称

    Nectin-4

  • 分子别名

    Ig superfamily receptor LNIR; Nectin cell adhesion molecule 4Imported; Poliovirus receptor-related protein 4; LNIR; PRR4; PVRL4; NECTIN4

  • 细胞定位

    Cell junction, Secreted, Cell membrane

  • Accession

    Q96NY8

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG1,k

  • 反应种属 ?

    Hu

  • 纯化方式

    Protein A

  • 浓度

    5 mg/ml

  • 内毒素含量

    <1EU/mg

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, containing no preservative

  • 储存条件

    2 to 8 °C for 2 weeks under sterile conditions;
    -20 °C for 3 months under sterile conditions;
    -80 °C for 24 months under sterile conditions.
    Please avoid repeated freeze-thaw cycles.

  • 应用

    Blocking of Nectin-4 signaling Functional assays

背景介绍

  • Nectin-4 (Poliovirus Receptor Related 4) is a transmembrane protein expressed on the cell surface that primarily functions during embryonic development, with minimal expression in healthy adult tissues. However, it is found to be aberrantly overexpressed in various malignancies—such as urothelial carcinoma, breast cancer, and lung cancer—where it correlates with tumor proliferation, metastasis, and poor prognosis, making it a highly promising therapeutic target. Targeted therapies developed against Nectin-4, particularly antibody-drug conjugates (ADCs), can precisely recognize and bind to tumor cells to deliver cytotoxic payloads, demonstrating significant clinical efficacy in treating urothelial carcinoma

  • 免疫印迹

    • WB result of Anti-Human Nectin-4 Monoclonal Antibody (Enfortumab)
      Primary antibody: Anti-Human Nectin-4 Monoclonal Antibody (Enfortumab) at 1/1000 dilution
      Lane 1: Nectin-4 His Tag Protein, Human 1 µg
      Lane 2: Nectin-4 His Tag Protein, Cynomolgus 1 µg
      Secondary antibody: Goat Anti- human IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 55 kDa
      Observed MW: 38-50 kDa

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