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Invivo anti-Mouse/Human CD44 Recombinant mAb

CDw44,Epican,Extracellular matrix receptor III (ECMR-III),GP90 lymphocyte homing/adhesion receptor,HUTCH-I,Heparan sulfate proteoglycan,Hermes antigen,Hyaluronate receptor,Phagocytic glycoprotein 1 (PGP-1),Phagocytic glycoprotein I (PGP-I),LHR,MDU2,MDU3,MIC4

价格 ￥700.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B7072
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rat

  • 抗原名称

    CD44

  • 分子别名

    CDw44; Epican; Extracellular matrix receptor III (ECMR-III); GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1 (PGP-1); Phagocytic glycoprotein I (PGP-I); LHR; MDU2; MDU3; MIC4

  • 细胞定位

    Cell membrane

  • Accession

    P16070, P15379

  • 克隆号

    IM7

  • 抗体类型

    Rat mAb

  • 抗体同种型

    Rat IgG2b,k

  • 同型对照

    Invivo rat IgG2b isotype control, anti-keyhole limpet hemocyanin

  • 反应种属 ?

    Hu, Ms

  • 阳性样本

    Human PBMC

  • 纯化方式

    Protein G

  • 浓度

    5 mg/ml

  • 纯度

    >95% (Determined by SDS-PAGE)

  • 内毒素含量

    <1EU/mg

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, containing no preservative

  • 储存条件

    2 to 8 °C for 2 weeks under sterile conditions;
    -20 °C for 3 months under sterile conditions;
    -80 °C for 24 months under sterile conditions.
    Please avoid repeated freeze-thaw cycles.

  • 应用

    in vivo blocking

    in vitro blocking

    FCM

  • 稀释度

    应用 稀释度 推荐种属
    FCM 1:1000 Hu, Ms
背景介绍

  • CD44 is a widely expressed transmembrane glycoprotein on the cell surface, belonging to the adhesion molecule family. It primarily functions as a receptor for hyaluronic acid (HA) and mediates cell-cell and cell-matrix interactions. Its structure includes variant exon-spliced isoforms (e.g., CD44v) and a constant region (CD44s), with post-translational modifications such as glycosylation generating multiple variants. CD44 plays crucial roles in physiological and pathological processes, including inflammation, wound healing, lymphocyte homing, and tumor metastasis. It is highly expressed in cancer stem cells (CSCs) and is associated with tumor progression, drug resistance, and poor prognosis. Key signaling pathways involving CD44 include PI3K/AKT and RAS/MAPK, making it a potential therapeutic target in cancer and stem cell research.

  • 流式分析

    • Flow cytometric analysis of human PBMC (human peripheral blood mononuclear cells) labelling CD44 antibody at 1/1000 dilution (0.5 μg) / (right panel) compared with a Rat IgG2b, κ Isotype Control / (left panel). Goat Anti-Rat IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD62L - Allophycocyanin antibody separately. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.

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