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宿主来源
Rat抗原名称
ICOS分子别名
Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; CD28 and CTLA-4-like protein (CCLP); CD28-related protein 1 (CRP-1); CD278; Ailim; Icos细胞定位
Cell membraneAccession
Q9WVS0克隆号
7E.17G9抗体类型
Rat mAb抗体同种型
Rat IgG2b,k同型对照
Invivo rat IgG2b isotype control, anti-keyhole limpet hemocyanin纯化方式
Protein G浓度
5 mg/ml纯度
>95%(Determined by SDS-PAGE)内毒素含量
<1EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, containing no preservative
储存条件
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.应用
in vivo blocking of ICOS/ICOSL signaling
FCM
ICOS (inducible T-cell costimulator, CD278) is a 55–60 kDa disulfide-linked homodimeric CD28-superfamily receptor expressed mainly on activated CD4⁺ and CD8⁺ T cells, Th17, Tfh and some NK subsets; its surface engagement by the ligand ICOSL (B7-H2/CD275) on antigen-presenting cells delivers a critical secondary signal that amplifies PI3K–AKT–mTOR and MAPK cascades, enhances cytokine transcription (IL-4, IL-10, IL-17, IL-21, IFN-γ), stabilizes Tfh differentiation, germinal-center reactions and class-switch recombination, and promotes memory formation, whereas genetic loss or therapeutic blockade of ICOS attenuates autoimmune pathology in experimental allergic encephalomyelitis, lupus, colitis and graft-versus-host disease yet can dampen antitumor immunity, making the pathway a finely balanced target for both immunosuppressive and immunostimulatory clinical interventions.
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