Invivo Anti-Mouse/Human/Rat Osteopontin (SPP1) Recombinant mAb

Osteopontin (OPN), encoded by the secreted phosphoprotein 1 (SPP1) gene, is a multifunctional 34-kDa matricellular glycoprotein rich in aspartic acid and serine phosphorylation sites that undergoes extensive alternative splicing and post-translational modifications (glycosylation, phosphorylation, sulfation, proteolytic cleavage) to generate multiple isoforms; it is secreted by osteoblasts, immune cells, epithelial and endothelial cells, and platelets, and it binds integrins (αvβ3, αvβ1, αvβ5, CD44 variants) and CD44 itself to regulate cell adhesion, migration, survival, and matrix remodeling, thereby orchestrating physiological processes such as bone mineralization, wound healing, and angiogenesis, while pathologically promoting chronic inflammation, tumor metastasis, fibrosis, and vascular calcification through activation of PI3K/Akt, MAPK/ERK, NF-κB, and TGF-β signaling cascades; its circulating levels rise in response to injury, infection, obesity, and cancer, making it a prognostic biomarker and therapeutic target across cardiovascular, renal, autoimmune, and neoplastic diseases.