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产品中心 抗体 功能性抗体

Invivo anti-Rat CD47 Recombinant mAb

Leukocyte surface antigen CD47,Integrin-associated protein (IAP),Cd47

价格 ￥1,050.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B7055
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Mouse

  • 抗原名称

    CD47

  • 分子别名

    Leukocyte surface antigen CD47; Integrin-associated protein (IAP); Cd47

  • 细胞定位

    Cell membrane

  • Accession

    P97829

  • 克隆号

    OX-101

  • 抗体类型

    Mouse mAb

  • 同型对照

    Invivo mouse IgG1 isotype control

  • 反应种属 ?

    Rt

  • 纯化方式

    Protein G

  • 浓度

    5 mg/ml

  • 纯度

    >95% (Determined by SDS-PAGE)

  • 内毒素含量

    <1EU/mg

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, containing no preservative

  • 储存条件

    2 to 8 °C for 2 weeks under sterile conditions;
    -20 °C for 3 months under sterile conditions;
    -80 °C for 24 months under sterile conditions.
    Please avoid repeated freeze-thaw cycles.

  • 应用

    in vivo blockade of CD47

    in vitro blockade of CD47

    FCM

背景介绍

  • CD47 is a ubiquitously expressed transmembrane glycoprotein that serves as a critical “don’t-eat-me” signal by engaging signal-regulatory protein α (SIRPα) on macrophages and dendritic cells, thereby inhibiting phagocytosis and bridging innate and adaptive immunity; beyond immune evasion, CD47 modulates integrin activation, cell adhesion, migration, apoptosis, and metabolic signaling, and its marked over-expression on diverse tumor cells—driven by oncogenic pathways such as KRAS-PI3K-STAT3, hypoxia-HIF-1α, or amino-acid-mTOR cascades—correlates with reduced patient survival, making blockade of the CD47–SIRPα axis a promising therapeutic strategy to restore anti-tumor immunity.

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