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Invivo anti-Mouse CD3ε Recombinant mAb

T-cell surface glycoprotein CD3 epsilon chain,T-cell surface antigen T3/Leu-4 epsilon chain,Cd3e

价格 ￥700.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B7048
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Armenian hamster

  • 抗原名称

    CD3ε

  • 分子别名

    T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; Cd3e

  • 细胞定位

    Cell membrane

  • Accession

    P22646

  • 克隆号

    145-2C11

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    Armenian hamster IgG

  • 同型对照

    Invivo Armenian Hamster IgG Isotype Control

  • 反应种属 ?

    Ms

  • 纯化方式

    Protein G

  • 浓度

    5 mg/ml

  • 纯度

    >95%(Determined by SDS-PAGE)

  • 内毒素含量

    <1EU/mg

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, containing no preservative

  • 储存条件

    2 to 8 °C for 2 weeks under sterile conditions;
    -20 °C for 3 months under sterile conditions;
    -80 °C for 24 months under sterile conditions.
    Please avoid repeated freeze-thaw cycles.

  • 应用

    in vitro T cell stimulation/activation

    in vivo T cell depletion

    FCM

背景介绍

  • CD3ε protein, also known as CD3E, is a crucial component of the T-cell receptor (TCR) complex, which is essential for T-cell activation and function. It is a single-pass type I membrane glycoprotein that contains one Ig-like domain and one immunoreceptor tyrosine-based activation motif (ITAM) domain. CD3ε, along with CD3γ, CD3δ, and CD3ζ, forms the TCR-CD3 complex, which plays a vital role in coupling antigen recognition to intracellular signal-transduction pathways. This protein is essential for the proper development of T-cells and is involved in the internalization and downregulation of the TCR-CD3 complex on the cell surface. Defects in the CD3ε gene can lead to severe immunodeficiency and have been linked to a susceptibility to type I diabetes in women.

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