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Invivo anti-Mouse CD119 Recombinant mAb

Interferon gamma receptor 1,IFN-gamma receptor 1,IFN-gamma-R1,Interferon gamma receptor alpha-chain (IFN-gamma-R-alpha),Ifngr,Ifngr1

价格 ￥1,050.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B7047
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rat

  • 抗原名称

    CD119

  • 分子别名

    Interferon gamma receptor 1; IFN-gamma receptor 1; IFN-gamma-R1; Interferon gamma receptor alpha-chain (IFN-gamma-R-alpha); Ifngr; Ifngr1

  • 细胞定位

    Cell membrane

  • Accession

    P15261

  • 克隆号

    GR-20

  • 抗体类型

    Rat mAb

  • 抗体同种型

    Rat IgG2a,k

  • 同型对照

    Invivo rat IgG2a isotype control, anti-trinitrophenol

  • 反应种属 ?

    Ms

  • 纯化方式

    Protein G

  • 浓度

    5 mg/ml

  • 纯度

    >95%(Determined by SDS-PAGE)

  • 内毒素含量

    <1EU/mg

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, containing no preservative

  • 储存条件

    2 to 8 °C for 2 weeks under sterile conditions;
    -20 °C for 3 months under sterile conditions;
    -80 °C for 24 months under sterile conditions.
    Please avoid repeated freeze-thaw cycles.

  • 应用

    In vivo IFNγR neutralization

    In vitro IFNγR neutralization

    FCM

背景介绍

  • CD119, also termed IFN-γ receptor 1 (IFNGR1), is a 54 kDa type-II cytokine receptor that forms, together with IFNGR2, the high-affinity heterotetrameric receptor for interferon-γ; upon IFN-γ binding it recruits JAK1 and JAK2 to phosphorylate STAT1, thereby driving transcription of antiviral, antigen-presentation and pro-inflammatory genes that activate macrophages, enhance Th1 responses and enforce host defence against intracellular pathogens, while inherited mutations in CD119 cause Mendelian susceptibility to mycobacterial disease.

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