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Invivo Anti-Mouse GITR Recombinant mAb

Tumor necrosis factor receptor superfamily member 18,Glucocorticoid-induced TNFR-related protein,CD357,Gitr,Tnfrsf18

价格 ￥700.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B7042
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rat

  • 抗原名称

    GITR

  • 分子别名

    Tumor necrosis factor receptor superfamily member 18; Glucocorticoid-induced TNFR-related protein; CD357; Gitr; Tnfrsf18

  • 细胞定位

    Cell membrane

  • Accession

    O35714

  • 克隆号

    DTA-1

  • 抗体类型

    Rat mAb

  • 抗体同种型

    Rat IgG2b, λ

  • 同型对照

    Invivo rat IgG2b isotype control, anti-keyhole limpet hemocyanin

  • 纯化方式

    Protein G

  • 浓度

    5 mg/ml

  • 纯度

    >95% (Determined by SDS-PAGE)

  • 内毒素含量

    <1EU/mg

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, containing no preservative

  • 储存条件

    2 to 8 °C for 2 weeks under sterile conditions;
    -20 °C for 3 months under sterile conditions;
    -80 °C for 24 months under sterile conditions.
    Please avoid repeated freeze-thaw cycles.

  • 应用

    in vivo GITR stimulation

    FCM

背景介绍

  • GITR (glucocorticoid-induced TNF receptor, TNFRSF18/CD357) is a cell-surface receptor of the TNF-receptor superfamily that is constitutively expressed at high levels on regulatory T cells (Tregs) and is rapidly up-regulated on activated CD4⁺/CD8⁺ T cells and NK cells; engagement of GITR by its ligand GITRL (TNFSF18) on antigen-presenting cells delivers a costimulatory signal that activates the NF-κB pathway, enhances IL-2 and IFN-γ production, up-regulates the anti-apoptotic protein Bcl-xL, and thereby amplifies effector T-cell proliferation, cytokine secretion and cytotoxicity while transiently destabilizing FoxP3 and the suppressive function of Tregs, making GITR an attractive target for cancer immunotherapy.

  • 流式分析

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