分享产品介绍 评论(0)
宿主来源
Rat抗原名称
CLEC9A (CD370)分子别名
C-type lectin domain family 9 member A; Dendritic cell natural killer lectin group receptor 1; Dngr-1; Clec9a细胞定位
MembraneAccession
Q8BRU4克隆号
7H11抗体类型
Rat mAb抗体同种型
Rat IgG1,k同型对照
Invivo rat IgG1 Isotype control, anti-trinitrophenol反应种属 ?
Ms纯化方式
Protein G浓度
5 mg/ml纯度
>95%(Determined by SDS-PAGE)内毒素含量
<1EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS, pH 7.4, Contains no stabilizers or preservatives
储存条件
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.应用
in vivo CLEC9A blockade
FCM
CD370, also known as CLEC9A or DNGR-1, is a type II transmembrane glycoprotein expressed almost exclusively on human CD141⁺ (mouse CD8α⁺) dendritic cells and a minor subset of CD14⁺CD16⁻ monocytes; it functions as an endocytic pattern-recognition receptor that binds exposed filamentous actin on necrotic cell debris, triggering Syk–ITAM signaling that drives efficient cross-presentation of dead-cell antigens to cytotoxic T lymphocytes and thereby links necrosis sensing to initiation of adaptive immunity.
评论(0)