Invivo anti-Mouse CD8α Recombinant mAb, F(ab’)2 Fragment

CD8α is a crucial immune glycoprotein that serves as a co-receptor for the MHC I-peptide complex, facilitating the recognition of antigens presented by APCs (antigen-presenting cells) to T cells. It is a key component of the CD8 receptor complex, which is predominantly found on cytotoxic T lymphocytes (CTLs). CD8α can form either an α/β heterodimer with CD8β or an α/α homodimer, both of which play essential roles in CTL activation and function. By interacting with the TCR (T cell receptor) and MHC I molecules, CD8α helps recruit the LCK kinase, initiating multiple signaling pathways that drive the CTL-mediated immune response.

This product is a F(ab) fragment derived from the anti-mouse CD8α antibody clone 2.43. Unlike full-length antibodies, this F(ab) fragment contains only the antigen-binding region and lacks the Fc domain, allowing specific binding to CD8α while eliminating Fc-mediated effects such as complement activation and Fcγ receptor engagement.

This Fc-free format is suitable for studies requiring CD8α targeting without inducing immune effector functions, antibody cross-linking, or CD8⁺ T cell depletion. It can also be applied in targeted delivery strategies, such as nanoparticle-based systems for selective CD8⁺ T cell targeting and in vivo delivery of genetic payloads.