分享产品介绍 评论(0)
宿主来源
Rat抗原名称
IL-12 p70分子别名
Interleukin-12细胞定位
SecretedAccession
P29459, P29460克隆号
20C2抗体类型
Rat mAb抗体同种型
Rat IgG1,k同型对照
Invivo rat IgG1 Isotype control, anti-trinitrophenol反应种属 ?
Hu纯化方式
Protein G浓度
5 mg/ml纯度
>95%(Determined by SDS-PAGE)内毒素含量
<1EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, containing no preservative
储存条件
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.应用
in vitro neutralization
Functional Assay
in vivo neutralization
ELISA
WB
稀释度
应用 稀释度 推荐种属 WB 1:1000 Hu
Interleukin-12 p70 (IL-12 p70) is a disulfide-linked heterodimeric cytokine composed of a 35-kDa light chain (p35) and a 40-kDa heavy chain (p40), functioning as the biologically active form of IL-12 secreted primarily by antigen-presenting cells such as dendritic cells, macrophages, and B cells upon recognition of pathogens; it drives the differentiation of naïve CD4+ T cells toward the Th1 phenotype, synergizes with IL-18 to induce large amounts of IFN-γ from T and NK cells, bridges innate and adaptive immunity, and is implicated in protective immunity against intracellular bacteria, viruses, and tumors, yet its dysregulation contributes to autoimmune and inflammatory disorders.
评论(0)