Invivo Anti-Mouse VISTA Recombinant mAb
V-type immunoglobulin domain-containing suppressor of T-cell activation,Platelet receptor Gi24,V-set domain-containing immunoregulatory receptorImported,V-set immunoregulatory receptorImported,Dies1,PD-1H,Vsir
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宿主来源
Armenian hamster抗原名称
VISTA分子别名
V-type immunoglobulin domain-containing suppressor of T-cell activation; Platelet receptor Gi24; V-set domain-containing immunoregulatory receptorImported; V-set immunoregulatory receptorImported; Dies1; PD-1H; Vsir细胞定位
Cell membraneAccession
Q9D659克隆号
S-3827抗体类型
Recombinant mAb抗体同种型
Armenian hamster IgG同型对照
Invivo Armenian Hamster IgG Isotype Control纯化方式
Protein G浓度
5 mg/ml纯度
>95%(Determined by SDS-PAGE)内毒素含量
<1EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS, pH 7.4, Contains no stabilizers or preservatives
储存条件
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.应用
in vivo blocking of VISTA signaling
in vitro blocking of VISTA signaling
ELISA
VISTA (V-domain Ig suppressor of T-cell activation), also known as B7-H5, PD-1H, C10orf54, Dies1, Gi24 or SISP1, is a type I transmembrane immune-checkpoint protein of the B7-CD28 family that is highly expressed on myeloid and granulocytic cells and at lower levels on CD4+ and CD8+ T cells; it functions both as an inhibitory receptor and as a ligand on antigen-presenting cells to suppress T-cell activation, maintain peripheral tolerance, modulate innate and adaptive anti-tumour immunity, and may additionally regulate embryonic stem-cell differentiation via BMP4 inhibition and stimulate MMP14-mediated MMP2 activation.
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