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宿主来源
Mouse抗原名称
CD47分子别名
Leukocyte surface antigen CD47; Antigenic surface determinant protein OA3; Integrin-associated protein (IAP); Protein MER6; MER6细胞定位
Cell membraneAccession
Q08722, Q61735, P97829克隆号
S-3748抗体类型
Recombinant mAb抗体同种型
Mouse IgG1, κ同型对照
Invivo mouse IgG1 isotype control反应种属 ?
Hu, Ms, Rt纯化方式
Protein G浓度
5 mg/ml纯度
>95%(Determined by SDS-PAGE)内毒素含量
<1EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS, pH 7.4, Contains no stabilizers or preservatives
储存条件
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.应用
in vitro CD47 blocking
in vivo CD47 blockade
ELISA
CD47, also known as integrin-associated protein, is a ubiquitously expressed cell surface receptor that belongs to the immunoglobulin superfamily. It is widely known for its role in preventing macrophage-mediated phagocytosis by interacting with signal regulatory protein alpha (SIRPα) on phagocytic cells. This “don’t eat me” signal is crucial for the survival of healthy cells, but cancer cells often overexpress CD47 to evade immune attack. In addition to its role in immune regulation, CD47 is involved in various cellular processes, including cell adhesion, migration, and the regulation of autophagy and cell death. For instance, it can regulate the migration of immune cells like neutrophils and dendritic cells, and its interaction with thrombospondin-1 (TSP-1) can induce apoptosis in certain cell types. Due to its significant role in cancer immunotherapy, CD47 has become an important target for developing new therapeutic strategies.
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