Invivo anti-mouse IFNAR-1 Recombinant mAb

IFNAR-1 (interferon-alpha/beta receptor subunit 1) is a single-pass type I membrane glycoprotein encoded by the IFNAR1 gene on human chromosome 21, and it constitutes the ligand-binding α-chain of the heterodimeric class II cytokine receptor for type I interferons (IFN-α/β/λ); upon IFN engagement, IFNAR-1 undergoes conformational coupling with its co-receptor IFNAR-2 to nucleate an intracellular signaling platform that recruits and activates the Janus kinases TYK2 and JAK1, leading to phosphorylation and nuclear translocation of STAT1/STAT2, formation of the ISGF3 transcriptional complex (with IRF9), and expression of hundreds of interferon-stimulated genes whose products orchestrate antiviral, antiproliferative, and immunomodulatory effects; structurally, the extracellular region adopts a tandem fibronectin-III–like fold that docks IFN, while the cytoplasmic tail harbors motifs that stabilize TYK2 binding and ubiquitination sites that viruses such as influenza A exploit to trigger IFNAR-1 degradation and evade innate immunity; the receptor is expressed broadly on hematopoietic and non-hematopoietic cells, and its regulated membrane turnover—controlled by phosphorylation, ubiquitin ligases, and microRNAs like miR-93-5p—fine-tunes cellular responsiveness to type I IFNs during infection, autoimmunity, and cancer immunosurveillance.