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宿主来源
Rat抗原名称
IL-7Rα (CD127)分子别名
Interleukin-7 receptor subunit alpha; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; Il7r细胞定位
MembraneAccession
P16872克隆号
A7R34抗体类型
Recombinant mAb抗体同种型
Rat IgG2a,k同型对照
Invivo rat IgG2a isotype control, anti-trinitrophenol反应种属 ?
Ms纯化方式
Protein A浓度
5 mg/ml纯度
>95% (Determined by SDS-PAGE)内毒素含量
<2EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
in vivo blocking of IL-7Rα signaling
稀释度
应用 稀释度 推荐种属 WB 1:1000 Ms
Interleukin-7 receptor α chain (IL-7Rα, CD127) is a 75 kDa type-I transmembrane glycoprotein that forms the cytokine-binding subunit of both the IL-7 receptor (IL-7R) and the thymic stromal lymphopoietin receptor (TSLPR); upon binding IL-7 it heterodimerizes with the common gamma chain (γc, CD132) to initiate JAK1/JAK3-mediated phosphorylation of STAT5, thereby driving survival, proliferation and differentiation of T, B and innate lymphoid cells, while TSLP engagement pairs IL-7Rα with the TSLPR chain to modulate type-2 immunity.
免疫印迹
WB result of Invivo anti-mouse IL-7Rα (CD127) Recombinant mAb
Primary antibody: Invivo anti-mouse IL-7Rα (CD127) Recombinant mAb at 1/1000 dilution
Lane 1: IL-7R alpha/CD127 Fc Chimera Protein, Mouse 2 µg
Lane 2: IL-7R alpha/CD127 Fc Chimera Protein, Human 2 µg
Secondary antibody: Goat Anti-rat IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 52 kDa
Observed MW: 60-90 kDa
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