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Invivo anti-mouse CD96 Recombinant mAb

T-cell surface protein tactile,Cell surface antigen CD96,T cell-activated increased late expression protein,Cd96

价格 ￥900.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B7007
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rat

  • 抗原名称

    CD96

  • 分子别名

    T-cell surface protein tactile; Cell surface antigen CD96; T cell-activated increased late expression protein; Cd96

  • 细胞定位

    Membrane

  • Accession

    Q3U0X8

  • 克隆号

    3.3

  • 抗体类型

    Rat mAb

  • 抗体同种型

    IgG1,λ

  • 同型对照

    Invivo rat IgG1 Isotype control, anti-trinitrophenol

  • 反应种属 ?

    Ms

  • 纯化方式

    Protein G

  • 浓度

    5 mg/ml

  • 纯度

    >95% (Determined by SDS-PAGE)

  • 内毒素含量

    <2EU/mg

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

  • 应用

    in vivo CD96 blocking

    in vitro CD96 blocking

    ELISA

背景介绍

  • CD96, also known as TACTILE (T cell activation, increased late expression), is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily, encoded by the CD96 gene. It is primarily expressed on T cells and natural killer (NK) cells, and is involved in immune regulation. CD96 shares sequence similarity with CD226 (DNAM-1) and competes with it for binding to CD155, its main ligand. This interaction can inhibit NK cell function and cytokine responses, making CD96 a potential target for cancer immunotherapy. Research has shown that blocking CD96 can enhance antitumor immunity, particularly when combined with other treatments such as anti-PD-1 or anti-CTLA-4 therapies. Additionally, CD96 expression is associated with immune infiltration and poor clinical outcomes in some cancers, further highlighting its potential as a therapeutic target.

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