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Invivo anti-mouse c-Kit (CD117) Recombinant mAb

Mast/stem cell growth factor receptor Kit,SCFR,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,CD117,Sl,Kit

价格 ￥700.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B7006
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rat

  • 抗原名称

    c-Kit (CD117)

  • 分子别名

    Mast/stem cell growth factor receptor Kit; SCFR; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; CD117; Sl; Kit

  • 细胞定位

    Cell membrane, Cytoplasm

  • Accession

    P05532

  • 克隆号

    ACK2

  • 抗体类型

    Rat mAb

  • 抗体同种型

    Rat IgG2b,k

  • 同型对照

    Invivo rat IgG2b isotype control, anti-keyhole limpet hemocyanin

  • 反应种属 ?

    Ms

  • 纯化方式

    Protein G

  • 浓度

    5 mg/ml

  • 纯度

    >95% (Determined by SDS-PAGE)

  • 内毒素含量

    <2EU/mg

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4

  • 储存条件

    2 to 8 °C for 2 weeks under sterile conditions;
    -20 °C for 3 months under sterile conditions;
    -80 °C for 24 months under sterile conditions.
    Please avoid repeated freeze-thaw cycles.

  • 应用

    in vivo c-Kit+ cell depletion

    in vitro c-Kit neutralization

    in vivo mast cell depletion

    FCM

  • 稀释度

    应用 稀释度 推荐种属
    FCM 1:500 Ms
背景介绍

  • c-Kit (CD117) is a receptor tyrosine kinase encoded by the c-kit gene. It plays a crucial role in the development and function of various cell types including hematopoietic cells, melanocytes, and gastrointestinal interstitial cells. The ligand for c-Kit is stem cell factor (SCF), and the binding of SCF to c-Kit activates intracellular signaling pathways that promote cell proliferation, survival, differentiation, and migration. Mutations or overexpression of c-Kit are associated with several diseases such as gastrointestinal stromal tumors (GISTs) and certain types of leukemia, making it an important target for therapeutic interventions.

  • 流式分析

    • Flow cytometric analysis of BALB/c mouse bone marrow labelling Mouse c-Kit antibody at 1/500 (1 μg) dilution/ (right panel) compared with a Rat IgG2b, κ Isotype Control / (left panel). Goat Anti-Rat IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD34 - FITC antibody separately.

    • Flow cytometric analysis of BALB/c mouse bone marrow labelling Mouse c-Kit antibody at 1/500 (1 μg) dilution/ (right panel) compared with a Rat IgG2b, κ Isotype Control / (left panel). Goat Anti-Rat IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with Lineage Cocktail - Brilliant Violet 421™ antibody separately.

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