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宿主来源
Rat抗原名称
CD41分子别名
Integrin alpha-IIb; GPalpha IIb (GPIIb); Platelet membrane glycoprotein IIb; Itga2b细胞定位
MembraneAccession
Q9QUM0克隆号
S-R690抗体类型
Rat mAb抗体同种型
IgG1,k反应种属 ?
Ms阳性样本
C57BL/6 mouse blood cells纯化方式
Protein G浓度
Lot specific* (generally 2 to 10 mg/ml)*纯度
>95% (Determined by SDS-PAGE)标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
应用
Cytotoxicity ,Depletion ,Induction ,Inhibition ,FCM稀释度
应用 稀释度 推荐种属 FCM 1:500 Ms
CD41, also known as integrin αIIb or platelet glycoprotein IIb, is a crucial protein involved in platelet aggregation and hemostasis. It is encoded by the ITGA2B gene and forms a heterodimer with integrin β3 (CD61) to create the fibrinogen receptor on platelets. This receptor is essential for platelet aggregation, as it binds soluble fibrinogen and other ligands like plasminogen, prothrombin, thrombospondin, vitronectin, and von Willebrand factor. Mutations in the CD41 gene can lead to Glanzmann thrombasthenia, a bleeding disorder characterized by prolonged bleeding after injury. CD41 is also used as a marker to identify platelets, megakaryocytes, and hematopoietic progenitor cells.
流式分析
Flow cytometric analysis of C57BL/6 mouse blood cells labelling CD41 antibody at 1/500 dilution (1 μg) / (Red) compared with a Rat IgG1, κ (Black) Isotype control and an unlabelled control (cells without incubation with primary antibody and secondary antibody) (Blue). Goat Anti - Rat IgG Alexa Fluor® 488 was used as the secondary antibody. Gated on total viable cells.
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