Phospho-GADS (Thr262) Recombinant Rabbit mAb (S-4987)

Phospho-GADS (Thr262) refers to the GRB2-related adaptor protein 2 (GADS) specifically phosphorylated at the threonine residue at position 262, a post-translational modification that critically regulates its function within intracellular signaling cascades, particularly in hematopoietic cells. As an adaptor protein lacking intrinsic enzymatic activity, GADS primarily serves as a molecular bridge linking upstream tyrosine kinases, such as ZAP-70 in T-cell receptor signaling or Syk in B-cell pathways, to downstream effectors like SLP-76, thereby facilitating the assembly of essential signalosomes required for immune cell activation, differentiation, and proliferation. The phosphorylation at Thr262 is believed to modulate GADS' conformational state or its affinity for binding partners, potentially influencing the stability, localization, or efficiency of these signaling complexes, and thus playing a pivotal role in fine-tuning cellular responses to external stimuli; dysregulation of this specific phosphorylation event may contribute to aberrant signaling associated with immunodeficiencies or lymphoid malignancies, making it a significant subject of study in understanding the precise molecular mechanisms governing adaptive immunity and potential therapeutic targeting.