IFI16 Recombinant Rabbit mAb (S-4089-44)

Interferon gamma-inducible protein 16 (IFI16), also known as PYHIN1 or p204 in mice, is a crucial member of the PYHIN family of nuclear proteins that functions primarily as a innate immune sensor for foreign DNA within the nucleus of human cells. Characterized by an N-terminal pyrin domain and two C-terminal HIN-200 domains responsible for DNA binding, IFI16 detects double-stranded DNA from invading pathogens such as herpesviruses (e.g., KSHV, HSV-1) and retroviruses (e.g., HIV-1), triggering the assembly of inflammasomes or activating the STING-TBK1-IRF3 signaling axis to induce type I interferon and pro-inflammatory cytokine production. Beyond its role in pathogen recognition, IFI16 acts as a tumor suppressor by regulating cell cycle progression, promoting cellular senescence, and inducing apoptosis through interactions with key regulators like p53 and Rb, while its expression and activity are tightly modulated by post-translational modifications and viral countermeasures that often seek to degrade or sequester the protein to evade immune detection.