热搜词：
注册
登录
CN
  • CN
  • EN

产品中心 抗体 其他一抗

所有图片（1/4）

RSK1/RSK2/RSK3 Recombinant Rabbit mAb (S-4982)

Ribosomal protein S6 kinase alpha-1,S6K-alpha-1,90 kDa ribosomal protein S6 kinase 1 (p90-RSK 1,p90RSK1,p90S6K),MAP kinase-activated protein kinase 1a (MAPK-activated protein kinase 1a,MAPKAP kinase 1a,MAPKAPK-1a),Ribosomal S6 kinase 1 (RSK-1),RPS6KA1,MAPKAPK1A,RSK1,Ribosomal protein S6 kinase alpha-2,S6K-alpha-2,90 kDa ribosomal protein S6 kinase 2 (p90-RSK 2,p90RSK2),MAP kinase-activated protein kinase 1c (MAPK-activated protein kinase 1c,MAPKAP kinase 1c,MAPKAPK-1c),Ribosomal S6 kinase 3 (RSK-3),pp90RSK3,RPS6KA2,MAPKAPK1C,RSK3,Ribosomal protein S6 kinase alpha-3,S6K-alpha-3,90 kDa ribosomal protein S6 kinase 3 (p90-RSK 3,p90RSK3),Insulin-stimulated protein kinase 1 (ISPK-1),MAP kinase-activated protein kinase 1b (MAPK-activated protein kinase 1b,MAPKAP kinase 1b,MAPKAPK-1b),Ribosomal S6 kinase 2 (RSK-2),pp90RSK2,RPS6KA3,ISPK1,MAPKAPK1B,RSK2

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B6896
规格
数量
收藏 分享
产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    RSK1/RSK2/RSK3

  • 分子别名

    Ribosomal protein S6 kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 kinase 1 (p90-RSK 1; p90RSK1; p90S6K); MAP kinase-activated protein kinase 1a (MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a); Ribosomal S6 kinase 1 (RSK-1); RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 kinase alpha-2; S6K-alpha-2; 90 kDa ribosomal protein S6 kinase 2 (p90-RSK 2; p90RSK2); MAP kinase-activated protein kinase 1c (MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c); Ribosomal S6 kinase 3 (RSK-3); pp90RSK3; RPS6KA2; MAPKAPK1C; RSK3; Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3 (p90-RSK 3; p90RSK3); Insulin-stimulated protein kinase 1 (ISPK-1); MAP kinase-activated protein kinase 1b (MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b); Ribosomal S6 kinase 2 (RSK-2); pp90RSK2; RPS6KA3; ISPK1; MAPKAPK1B; RSK2

  • 细胞定位

    Cytoplasm, Nucleus

  • Accession

    Q15418, P51812, Q15349

  • 克隆号

    S-4982

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Hu, Ms, Rt, Mk

  • 阳性样本

    HeLa, K562, A431, MCF7, HT-29, L-929, NIH/3T3, RAW264.7, AR42J, PC-12, COS-7

  • 纯化方式

    Protein A

  • 浓度

    0.5 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

  • 应用

    WB

  • 稀释度

    应用 稀释度 推荐种属
    WB 1:1000-1:2000 Hu, Ms, Rt, Mk
背景介绍

  • Ribosomal S6 Kinases 1, 2, and 3 (RSK1, RSK2, and RSK3) are serine/threonine kinases belonging to the p90 ribosomal S6 kinase (p90RSK) family, which function as critical downstream effectors of the Ras-MAPK/ERK signaling pathway to regulate diverse cellular processes including proliferation, survival, differentiation, and metabolism. These isoforms share a unique bimodal structure comprising an N-terminal kinase domain and a C-terminal kinase domain linked by a regulatory loop, where activation typically involves phosphorylation by ERK1/2 at the C-terminal domain followed by autophosphorylation and subsequent activation of the N-terminal domain to phosphorylate various substrates such as CREB, Bad, and GSK3β. While they exhibit high sequence homology and overlapping functions, RSK1, RSK2, and RSK3 display distinct tissue distribution patterns and specific physiological roles; for instance, RSK2 mutations are directly linked to Coffin-Lowry syndrome, a rare X-linked genetic disorder characterized by severe psychomotor retardation and skeletal abnormalities, highlighting the non-redundant importance of specific RSK isoforms in neural development and cognitive function, whereas RSK1 and RSK3 are often implicated in cancer progression and cardiac hypertrophy, making them significant targets for therapeutic intervention in oncology and cardiovascular diseases.

  • 免疫印迹

    • WB result of RSK1/RSK2/RSK3 Recombinant Rabbit mAb
      Primary antibody incubation conditions: overnight at 4°C
      Primary antibody: RSK1/RSK2/RSK3 Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: HeLa whole cell lysate 20 µg
      Lane 2: K562 whole cell lysate 20 µg
      Lane 3: A431 whole cell lysate 20 µg
      Lane 4: MCF7 whole cell lysate 20 µg
      Lane 5: HT-29 whole cell lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 83 kDa
      Observed MW: 85 kDa

    • WB result of RSK1/RSK2/RSK3 Recombinant Rabbit mAb
      Primary antibody incubation conditions: overnight at 4°C
      Primary antibody: RSK1/RSK2/RSK3 Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: L-929 whole cell lysate 20 µg
      Lane 2: NIH/3T3 whole cell lysate 20 µg
      Lane 3: RAW264.7 whole cell lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 83 kDa
      Observed MW: 85 kDa

    • WB result of RSK1/RSK2/RSK3 Recombinant Rabbit mAb
      Primary antibody incubation conditions: overnight at 4°C
      Primary antibody: RSK1/RSK2/RSK3 Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: AR42J whole cell lysate 20 µg
      Lane 2: PC-12 whole cell lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 83 kDa
      Observed MW: 85 kDa

    • WB result of RSK1/RSK2/RSK3 Recombinant Rabbit mAb
      Primary antibody incubation conditions: overnight at 4°C
      Primary antibody: RSK1/RSK2/RSK3 Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: COS-7 whole cell lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 83 kDa
      Observed MW: 85 kDa

评论(0)