Phospho-SLP-76 (Ser376) Recombinant Rabbit mAb (S-3106-47）

Phospho-SLP-76 (Ser376) refers to the SH2 domain-containing leukocyte protein of 76 kDa (SLP-76, also known as LCP2) specifically phosphorylated at the serine 376 residue, a critical post-translational modification that plays a pivotal regulatory role in T-cell receptor (TCR) signaling pathways. As an essential adaptor protein in hematopoietic cells, SLP-76 serves as a central hub for assembling the LAT signalosome, and its phosphorylation at Ser376, primarily mediated by kinases such as CK2 or potentially influenced by downstream MAPK pathways depending on the cellular context, modulates its interaction with other signaling molecules like Vav1 and Itk, thereby fine-tuning cytoskeletal reorganization, calcium flux, and transcriptional activation required for effective T-cell activation, differentiation, and immune response; consequently, the detection and analysis of Phospho-SLP-76 (Ser376) are vital for understanding the precise molecular mechanisms governing immune cell function and identifying potential therapeutic targets in immunological disorders and cancers.