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Phospho-p90RSK (Ser380) Recombinant Rabbit mAb (S-4985)

Ribosomal protein S6 kinase alpha-1,S6K-alpha-1,90 kDa ribosomal protein S6 kinase 1 (p90-RSK 1,p90RSK1,p90S6K),MAP kinase-activated protein kinase 1a (MAPK-activated protein kinase 1a,MAPKAP kinase 1a,MAPKAPK-1a),Ribosomal S6 kinase 1 (RSK-1),RPS6KA1,MAPKAPK1A,RSK1,Ribosomal protein S6 kinase alpha-2,S6K-alpha-2,90 kDa ribosomal protein S6 kinase 2 (p90-RSK 2,p90RSK2),MAP kinase-activated protein kinase 1c (MAPK-activated protein kinase 1c,MAPKAP kinase 1c,MAPKAPK-1c),Ribosomal S6 kinase 3 (RSK-3),pp90RSK3,RPS6KA2,MAPKAPK1C,RSK3,Ribosomal protein S6 kinase alpha-3,S6K-alpha-3,90 kDa ribosomal protein S6 kinase 3 (p90-RSK 3,p90RSK3),Insulin-stimulated protein kinase 1 (ISPK-1),MAP kinase-activated protein kinase 1b (MAPK-activated protein kinase 1b,MAPKAP kinase 1b,MAPKAPK-1b),Ribosomal S6 kinase 2 (RSK-2),pp90RSK2,RPS6KA3,ISPK1,MAPKAPK1B,RSK2

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B6893
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    Phospho-p90RSK (Ser380)

  • 分子别名

    Ribosomal protein S6 kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 kinase 1 (p90-RSK 1; p90RSK1; p90S6K); MAP kinase-activated protein kinase 1a (MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a); Ribosomal S6 kinase 1 (RSK-1); RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 kinase alpha-2; S6K-alpha-2; 90 kDa ribosomal protein S6 kinase 2 (p90-RSK 2; p90RSK2); MAP kinase-activated protein kinase 1c (MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c); Ribosomal S6 kinase 3 (RSK-3); pp90RSK3; RPS6KA2; MAPKAPK1C; RSK3; Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3 (p90-RSK 3; p90RSK3); Insulin-stimulated protein kinase 1 (ISPK-1); MAP kinase-activated protein kinase 1b (MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b); Ribosomal S6 kinase 2 (RSK-2); pp90RSK2; RPS6KA3; ISPK1; MAPKAPK1B; RSK2

  • 细胞定位

    Nucleus, Cytoplasm

  • Accession

    P51812, Q15349, Q15418

  • 克隆号

    S-4985

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Hu, Mk

  • 阳性样本

    HeLa (starved overnight, then treated with 200 nM TPA for 10 minutes), COS-7 (treated with 200 nM TPA for 30 minutes)

  • 纯化方式

    Protein A

  • 浓度

    0.5 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

  • 应用

    WB

  • 稀释度

    应用 稀释度 推荐种属
    WB 1:1000 Hu, Mk
背景介绍

  • Phospho-p90RSK (Ser380) refers to the p90 ribosomal S6 kinase (p90RSK) protein specifically phosphorylated at serine residue 380, a critical post-translational modification that serves as a key indicator of the kinase's activation status within the Ras/MAPK signaling pathway. As a downstream effector of ERK1/2, p90RSK undergoes sequential phosphorylation events where phosphorylation at Ser380 in the C-terminal kinase domain facilitates the subsequent phosphorylation of the N-terminal kinase domain, thereby fully activating the enzyme to regulate diverse cellular processes including cell proliferation, survival, differentiation, and motility. This specific phospho-epitope is widely utilized in biomedical research as a reliable biomarker for monitoring MAPK pathway activity and assessing the efficacy of targeted therapies in various pathological conditions, particularly in cancers where aberrant RSK signaling contributes to tumor growth and resistance to apoptosis.

  • 免疫印迹

    • WB result of Phospho-p90RSK (Ser380) Recombinant Rabbit mAb
      Blocking/Diluting buffer and concentration: 5% NFDM/TBST
      Primary antibody incubation conditions: overnight at 4°C
      Primary antibody: Phospho-p90RSK (Ser380) Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: untreated HeLa whole cell lysate 20 µg
      Lane 2: HeLa starved overnight, then treated with 200 nM TPA for 10 minutes whole cell lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 83 kDa
      Observed MW: 90 kDa

    • WB result of Phospho-p90RSK (Ser380) Recombinant Rabbit mAb
      Blocking/Diluting buffer and concentration: 5% NFDM/TBST
      Primary antibody incubation conditions: overnight at 4°C
      Primary antibody: Phospho-p90RSK (Ser380) Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: untreated COS-7 whole cell lysate 20 µg
      Lane 2: COS-7 treated with 200 nM TPA for 30 minutes whole cell lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 83 kDa
      Observed MW: 90 kDa

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