Phospho-AMPKα (Thr172) Recombinant Rabbit mAb (S-3592)
5'-AMP-activated protein kinase catalytic subunit alpha-1,AMPK subunit alpha-1,Acetyl-CoA carboxylase kinase (ACACA kinase),Hydroxymethylglutaryl-CoA reductase kinase (HMGCR kinase),Tau-protein kinase PRKAA1,AMPK1,PRKAA1
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宿主来源
Rabbit抗原名称
Phospho-AMPKα (Thr172)分子别名
5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase (ACACA kinase); Hydroxymethylglutaryl-CoA reductase kinase (HMGCR kinase); Tau-protein kinase PRKAA1; AMPK1; PRKAA1细胞定位
Cytoplasm, NucleusAccession
Q13131, P54646克隆号
S-3592抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Hu, Ms, Rt纯化方式
Protein A浓度
0.5 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
应用
WB
稀释度
应用 稀释度 推荐种属 WB 1:1000-1:2000 Hu, Ms, Rt
Phospho-AMPKα (Thr172) protein refers to the catalytic α-subunit of AMP-activated protein kinase that has been phosphorylated on threonine 172, a post-translational modification catalyzed primarily by the upstream kinase LKB1 (or CaMKK2 in response to calcium signals) that is essential for switching AMPK from an inactive to an active conformation; once phosphorylated, this evolutionarily conserved serine/threonine kinase acts as a master cellular energy sensor, triggering catabolic pathways such as fatty-acid oxidation and autophagy while simultaneously inhibiting energy-consuming anabolic processes like gluconeogenesis, lipogenesis and protein synthesis, thereby restoring ATP levels during metabolic stress, and its phosphorylation status is widely used as a biomarker for metabolic activity, exercise physiology, mitochondrial health and the efficacy of drugs ranging from metformin to direct AMPK activators in diabetes, cancer and cardiovascular research.
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