产品中心 蛋白翻译后修饰(PTM)抗体 位点特异性修饰抗体
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宿主来源
Rabbit抗原名称
N6-methyladenosine (m6A)克隆号
S-4340抗体类型
Recombinant mAb抗体同种型
IgG纯化方式
Protein A浓度
0.5 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, -20°C as supplied
稀释度
应用 稀释度 Dot Blot 1:2000-1:5000
N6-methyladenosine (m6A) is the most abundant and conserved internal chemical modification on eukaryotic messenger RNA (mRNA), referring to the reversible methylation of the nitrogen atom at the sixth position of adenosine. This modification is dynamically catalyzed by "writers" (such as the METTL3/METTL14 complex), removed by "erasers" (such as FTO and ALKBH5), and recognized by "reader" proteins (such as the YTH family) to regulate RNA fate. m6A plays a central role in key post-transcriptional processes including RNA splicing, nuclear export, translation efficiency, and degradation. It is extensively involved in mammalian development, immunity, neurological functions, and various diseases (especially cancer and metabolic disorders), making it a hot topic in the field of epitranscriptomics.
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