NMNAT1 Recombinant Rabbit mAb (S-3703-4)

NMNAT1 (Nicotinamide Mononucleotide Adenylyltransferase 1) is a nuclear-localized enzyme that serves as the rate-limiting catalyst in the final step of the NAD+ salvage pathway, converting nicotinamide mononucleotide (NMN) and ATP into nicotinamide adenine dinucleotide (NAD+). As the primary isoform responsible for maintaining nuclear NAD+ pools, NMNAT1 is essential for supporting the activity of NAD+-dependent enzymes such as PARPs (poly-ADP-ribose polymerases) and sirtuins, which are critical for DNA repair, genomic stability, and epigenetic regulation. Beyond its metabolic function, NMNAT1 acts as a potent neuroprotective factor; it has been shown to delay Wallerian degeneration and protect axons from injury-induced degradation, a property largely attributed to its ability to sustain local NAD+ levels and stabilize cellular energy homeostasis. Mutations in the NMNAT1 gene are associated with Leber congenital amaurosis type 9 (LCA9), a severe early-onset retinal dystrophy, highlighting its indispensable role in neuronal and retinal health.