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Lp-PLA2 Recombinant Rabbit mAb (S-3711-113)

Platelet-activating factor acetylhydrolase,PAF acetylhydrolase,1-alkyl-2-acetylglycerophosphocholine esterase,2-acetyl-1-alkylglycerophosphocholine esterase,Group-VIIA phospholipase A2 (gVIIA-PLA2),LDL-associated phospholipase A2 (LDL-PLA(2)),PAF 2-acylhydrolase,PAFAH,PLA2G7

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B6808
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    Lp-PLA2

  • 分子别名

    Platelet-activating factor acetylhydrolase; PAF acetylhydrolase; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; Group-VIIA phospholipase A2 (gVIIA-PLA2); LDL-associated phospholipase A2 (LDL-PLA(2)); PAF 2-acylhydrolase; PAFAH; PLA2G7

  • 免疫原

    Synthetic Peptide

  • 细胞定位

    Secreted

  • Accession

    Q13093

  • 克隆号

    S-3711-113

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Hu, Ms, Rt

  • 阳性样本

    THP-1 (treated with 100 nM PMA for 24 hours), PC-3, mouse liver, rat liver, rat lung

  • 纯化方式

    Protein A

  • 浓度

    2 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

  • 应用

    WB

  • 稀释度

    应用 稀释度 推荐种属
    WB 1:1000 Hu, Ms, Rt
背景介绍

  • Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as plasma platelet-activating factor acetylhydrolase, is an enzyme encoded by the PLA2G7 gene and belongs to the phospholipase A2 superfamily. It is primarily associated with lipoproteins in the bloodstream and plays a crucial role in lipid metabolism and inflammation. Lp-PLA2 hydrolyzes oxidized phospholipids, such as oxidized low-density lipoprotein (oxLDL), into lysophosphatidylcholine and non-esterified fatty acids, contributing to the progression of atherosclerosis. Additionally, it acts as a biomarker for vascular inflammation and is linked to various cardiovascular diseases. Recent studies have also revealed its involvement in ferroptosis, a form of regulated cell death, where Lp-PLA2 negatively regulates lipid peroxidation and protects cells from ferroptotic cell death.

  • 免疫印迹

    • WB result of Lp-PLA2 Recombinant Rabbit mAb
      Primary antibody: Lp-PLA2 Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: untreated THP-1 whole cell lysate 20 µg
      Lane 2: THP-1 treated with 100 nM PMA for 24 hours whole cell lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 50 kDa
      Observed MW: 45 kDa

    • WB result of Lp-PLA2 Recombinant Rabbit mAb
      Primary antibody: Lp-PLA2 Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: PC-3 whole cell lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 50 kDa
      Observed MW: 45 kDa
      This blot was developed with high sensitivity substrate

    • WB result of Lp-PLA2 Recombinant Rabbit mAb
      Primary antibody: Lp-PLA2 Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: mouse liver lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 50 kDa
      Observed MW: 45 kDa
      This blot was developed with high sensitivity substrate

    • WB result of Lp-PLA2 Recombinant Rabbit mAb
      Primary antibody: Lp-PLA2 Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: rat liver lysate 20 µg
      Lane 2: rat lung lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 50 kDa
      Observed MW: 45 kDa

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