Albumin Recombinant Rabbit mAb (S-1400-49)

Albumin, primarily referring to human serum albumin (HSA), is the most abundant protein in human blood plasma, synthesized exclusively by the liver, and serves as a critical multifunctional molecule essential for maintaining physiological homeostasis. Its primary role is to regulate colloid osmotic pressure, thereby preventing fluid leakage from blood vessels into surrounding tissues and ensuring proper blood volume, while simultaneously acting as a versatile carrier that binds and transports a wide array of endogenous substances such as fatty acids, hormones, bilirubin, and metal ions, as well as exogenous compounds including many pharmaceutical drugs, which significantly influences their distribution, metabolism, and efficacy. Structurally, albumin is a single-chain polypeptide with a molecular weight of approximately 66.5 kDa, characterized by high stability and a long half-life of about 19 days, featuring multiple binding sites that allow it to buffer pH changes and function as a major antioxidant by scavenging reactive oxygen species; clinically, serum albumin levels are a key indicator of liver synthetic function and nutritional status, where hypoalbuminemia often signals severe liver disease, kidney disorders like nephrotic syndrome, or chronic inflammation, making it an indispensable biomarker and therapeutic agent used globally to treat conditions such as shock, burns, and hypovolemia.