LYVE1 Recombinant Rabbit mAb (S-3786-26)
Lymphatic vessel endothelial hyaluronic acid receptor 1,Cell surface retention sequence-binding protein 1 (CRSBP-1),Extracellular link domain-containing protein 1,Hyaluronic acid receptor,CRSBP1,HAR,XLKD1
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宿主来源
Rabbit抗原名称
LYVE1分子别名
Lymphatic vessel endothelial hyaluronic acid receptor 1; Cell surface retention sequence-binding protein 1 (CRSBP-1); Extracellular link domain-containing protein 1; Hyaluronic acid receptor; CRSBP1; HAR; XLKD1免疫原
Recombinant Protein细胞定位
Cell membraneAccession
Q9Y5Y7克隆号
S-3786-26抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Hu纯化方式
Protein A浓度
0.5 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
应用
IHC-P ?
稀释度
应用 稀释度 推荐种属 IHC-P 1:1000 Hu
Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) is a type I integral membrane glycoprotein belonging to the Link protein superfamily, primarily characterized by its high-affinity binding to hyaluronan (HA), a major component of the extracellular matrix. Predominantly expressed on the surface of lymphatic endothelial cells in both developing and adult tissues, LYVE-1 serves as a definitive marker for identifying lymphatic vessels, distinguishing them from blood vessels, although it is also transiently found on liver sinusoidal endothelial cells and certain macrophage populations during embryogenesis or inflammation. Structurally, it shares homology with CD44, another HA receptor, yet possesses unique functional properties that facilitate the uptake and transport of HA from peripheral tissues into the lymphatic system, thereby playing a critical role in maintaining tissue fluid homeostasis, regulating immune cell trafficking, and modulating inflammatory responses. Beyond its physiological functions in lymphangiogenesis and HA clearance, LYVE-1 has significant clinical relevance as its expression is often upregulated in tumor-associated lymphatics, making it a valuable target for studying cancer metastasis and a potential diagnostic marker for lymphatic malformations and various carcinomas.
免疫组化
IHC shows positive staining in paraffin-embedded human colon. Anti-LYVE1 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human liver. Anti-LYVE1 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human spleen. Anti-LYVE1 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human tonsil. Anti-LYVE1 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
组织表达图谱
Expression of LYVE1 in tumor tissues.
Expression of LYVE1 in human tissues.
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