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宿主来源
Rabbit抗原名称
GLP1R分子别名
Glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R; GLP-1R免疫原
Recombinant Protein细胞定位
Cell membraneAccession
P43220克隆号
S-2200-163抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Hu纯化方式
Protein A浓度
0.5 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
应用
IHC-P ?
稀释度
应用 稀释度 推荐种属 IHC-P 1:500-1:1000 Hu
GLP1R (Glucagon-like peptide-1 receptor) is a G protein-coupled receptor (GPCR) primarily expressed in pancreatic β-cells, as well as in the brain, heart, and gastrointestinal tract. It is activated by the incretin hormone GLP-1 (glucagon-like peptide-1), which is secreted by intestinal L-cells in response to nutrient ingestion. Upon activation, GLP1R stimulates glucose-dependent insulin secretion, suppresses glucagon release, delays gastric emptying, and promotes satiety—making it a critical therapeutic target for type 2 diabetes mellitus and obesity. Notably, GLP1R agonists such as semaglutide and liraglutide have revolutionized metabolic disease management by mimicking endogenous GLP-1 action with enhanced stability and potency. Additionally, emerging evidence suggests neuroprotective and cardioprotective roles of GLP1R signaling, expanding its clinical relevance beyond glycemic control.
免疫组化
IHC shows positive staining in paraffin-embedded human pancreas. Anti-GLP1R antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
Negative control: IHC shows negative staining in paraffin-embedded human tonsil. Anti-GLP1R antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
组织表达图谱
Expression of GLP1R in tumor tissues.
Expression of GLP1R in human tissues.
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