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宿主来源
Rabbit抗原名称
Neutrophil Elastase (ELA2)分子别名
Elastase-2; Leukocyte elastase; Ela2; Elane免疫原
Synthetic Peptide细胞定位
CytoplasmAccession
Q3UP87克隆号
S-3766-3抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Ms纯化方式
Protein A浓度
0.5 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
应用
IHC-P ?
稀释度
应用 稀释度 推荐种属 IHC-P 1:2000 Ms
Neutrophil elastase is a serine protease stored in azurophilic granules of neutrophils, released during inflammation to degrade extracellular matrix components including elastin, collagen, and fibronectin. While essential for immune defense against pathogens, dysregulated activity contributes to tissue destruction in chronic inflammatory diseases such as chronic obstructive pulmonary disease (COPD), cystic fibrosis, and acute respiratory distress syndrome (ARDS). It also modulates inflammatory signaling by processing cytokines and chemokines, making it a therapeutic target for inflammatory and autoimmune conditions.
免疫组化
IHC shows positive staining in paraffin-embedded mouse liver. Anti-Neutrophil Elastase (ELA2) antibody was used at 1/2000 dilution, followed by a HRP Polymer for Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded mouse lung. Anti-Neutrophil Elastase (ELA2) antibody was used at 1/2000 dilution, followed by a HRP Polymer for Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded mouse spleen. Anti-Neutrophil Elastase (ELA2) antibody was used at 1/2000 dilution, followed by a HRP Polymer for Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
Negative control: IHC shows negative staining in paraffin-embedded mouse cerebral cortex. Anti-Neutrophil Elastase (ELA2) antibody was used at 1/2000 dilution, followed by a HRP Polymer for Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
组织表达图谱
Expression of Neutrophil Elastase (ELA2) in mouse & rat tissues.
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