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CaV2.3 (CACNA1E) Recombinant Rabbit mAb (S-3244-59)

Voltage-dependent R-type calcium channel subunit alpha-1E,Brain calcium channel II (BII),Calcium channel,L type,alpha-1 polypeptide,isoform 6,Voltage-gated calcium channel subunit alpha Cav2.3,CACH6,CACNL1A6

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B6718
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    CaV2.3 (CACNA1E)

  • 分子别名

    Voltage-dependent R-type calcium channel subunit alpha-1E; Brain calcium channel II (BII); Calcium channel; L type; alpha-1 polypeptide; isoform 6; Voltage-gated calcium channel subunit alpha Cav2.3; CACH6; CACNL1A6

  • 免疫原

    Synthetic Peptide

  • 细胞定位

    Membrane

  • Accession

    Q15878

  • 克隆号

    S-3244-59

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Ms, Rt

  • 阳性样本

    mouse brain, rat brain

  • 纯化方式

    Protein A

  • 浓度

    0.5 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

  • 应用

    IHC-P ?

    WB

  • 稀释度

    应用 稀释度 推荐种属
    WB 1:1000-1:2000 Ms, Rt
    IHC-P 1:2000 Ms, Rt
背景介绍

  • CaV2.3, encoded by the CACNA1E gene, is a member of the high-voltage-activated (HVA) R-type calcium channel family, distinguished by its unique biophysical properties including rapid activation and inactivation kinetics, single-channel conductance, and insensitivity to conventional dihydropyridine, ω-conotoxin GVIA, or ω-agatoxin IVA blockers. Predominantly expressed in the central nervous system—particularly in the cortex, hippocampus, cerebellum, and thalamus—this channel plays a critical role in regulating neuronal excitability, neurotransmitter release at specialized synapses, and synaptic plasticity. Functionally, CaV2.3 channels contribute to action potential repolarization, afterhyperpolarization, and pacemaking activities in specific neuronal populations, while also modulating calcium signaling pathways that influence gene transcription and neuronal survival. Clinically, gain-of-function mutations in CACNA1E have been associated with developmental and epileptic encephalopathies, autism spectrum disorders, and chronic pain conditions, whereas the channel represents a potential therapeutic target for epilepsy, neuropathic pain, and neurodegenerative diseases due to its distinct pharmacological profile and restricted neuronal distribution.

  • 免疫印迹

    • WB result of CaV2.3 (CACNA1E) Recombinant Rabbit mAb
      Primary antibody: CaV2.3 (CACNA1E) Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: unboiled mouse kidney lysate 20 µg
      Lane 2: unboiled mouse brain lysate 20 µg
      Negative control: unboiled mouse kidney lysate
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 262 kDa
      Observed MW: 350 kDa

    • WB result of CaV2.3 (CACNA1E) Recombinant Rabbit mAb
      Primary antibody: CaV2.3 (CACNA1E) Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: unboiled rat kidney lysate 20 µg
      Lane 2: unboiled rat brain lysate 20 µg
      Negative control: unboiled rat kidney lysate
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 262 kDa
      Observed MW: 350 kDa

  • 免疫组化

    • IHC shows positive staining in paraffin-embedded mouse cerebral cortex. Anti-CaV2.3 (CACNA1E) antibody was used at 1/2000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

    • Negative control: IHC shows negative staining in paraffin-embedded mouse kidney. Anti-CaV2.3 (CACNA1E) antibody was used at 1/2000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

    • IHC shows positive staining in paraffin-embedded rat cerebral cortex. Anti-CaV2.3 (CACNA1E) antibody was used at 1/2000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

    • Negative control: IHC shows negative staining in paraffin-embedded rat kidney. Anti-CaV2.3 (CACNA1E) antibody was used at 1/2000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

  • 组织表达图谱

    • Expression of CaV2.3 (CACNA1E) in mouse & rat tissues.

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