MSMB Recombinant Rabbit mAb (S-3400-1)

MSMB (Microseminoprotein Beta), also known as PSP94 (Prostate-Secretory Protein of 94 amino acids) or β-inhibin, is a small secreted protein predominantly expressed in the prostate gland and seminal plasma, where it functions as a major component of seminal fluid involved in immune modulation and sperm function. Encoded by the MSMB gene located on chromosome 10, this cysteine-rich protein contains approximately 94 amino acids and exhibits structural homology to the cystatin family of protease inhibitors, though its precise physiological role remains incompletely understood. MSMB has garnered significant clinical interest as a promising biomarker for prostate cancer detection and risk stratification, with numerous studies demonstrating that reduced serum or tissue levels of MSMB correlate with higher Gleason scores, advanced tumor stage, and increased risk of disease progression, potentially offering improved specificity compared to prostate-specific antigen (PSA) testing. Beyond its diagnostic utility, emerging research suggests MSMB may possess tumor suppressor properties through mechanisms involving inhibition of tumor cell proliferation, angiogenesis, and metastasis, while also participating in reproductive biology by regulating sperm motility and exhibiting antimicrobial activity against sexually transmitted pathogens. The protein's expression is androgen-regulated in prostatic tissue, and its downregulation during malignant transformation appears to occur through both epigenetic modifications and structural alterations in the prostate microenvironment, making it a subject of intense investigation for both liquid biopsy applications and therapeutic targeting in prostate cancer management.