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HIRA Recombinant Rabbit mAb (S-2928-13)

Protein HIRA,TUP1-like enhancer of split protein 1,DGCR1,HIR,TUPLE1

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B6696
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    HIRA

  • 分子别名

    Protein HIRA; TUP1-like enhancer of split protein 1; DGCR1; HIR; TUPLE1

  • 免疫原

    Synthetic Peptide

  • 细胞定位

    Nucleus

  • Accession

    P54198

  • 克隆号

    S-2928-13

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Hu, Ms, Rt, Mk

  • 阳性样本

    HeLa, HeLa, K562, HEK-293, 293T, HCT 116, mouse brain, rat brain, COS-7

  • 纯化方式

    Protein A

  • 浓度

    0.5 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

  • 应用

    WB

  • 稀释度

    应用 稀释度 推荐种属
    WB 1:1000 Hu, Ms, Rt, Mk
背景介绍

  • HIRA (Histone Cell Cycle Regulator) is a conserved histone chaperone that forms a multi-subunit complex—typically including UBN1, CABIN1, and ASF1a—to deposit the histone variant H3.3 into chromatin independently of DNA replication, thereby modulating nucleosome dynamics at transcriptionally active promoters, enhancers, and gene bodies; by stabilizing open chromatin states, HIRA underlies gene activation, embryonic development, stress-responsive transcription, senescence-associated heterochromatin formation, and DNA-damage repair, while its dysregulation or haploinsufficiency at human chromosome 22q11.21 has been linked to DiGeorge syndrome and tumorigenesis.

  • 免疫印迹

    • WB result of HIRA Recombinant Rabbit mAb
      Primary antibody: HIRA Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: HeLa whole cell hot lysate with 1% SDS 20 µg
      Lane 2: HeLa whole cell lysate 20 µg
      Lane 3: K562 whole cell lysate 20 µg
      Lane 4: HEK-293 whole cell lysate 20 µg
      Lane 5: 293T whole cell lysate 20 µg
      Lane 6: HCT 116 whole cell lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 112 kDa
      Observed MW: 120 kDa

    • WB result of HIRA Recombinant Rabbit mAb
      Primary antibody: HIRA Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: mouse brain lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 112 kDa
      Observed MW: 120 kDa

    • WB result of HIRA Recombinant Rabbit mAb
      Primary antibody: HIRA Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: rat brain lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 112 kDa
      Observed MW: 120 kDa

    • WB result of HIRA Recombinant Rabbit mAb
      Primary antibody: HIRA Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: COS-7 whole cell lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 112 kDa
      Observed MW: 120 kDa

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