CACNA1B Recombinant Rabbit mAb (S-2992-33)

CACNA1B protein, encoded by the CACNA1B gene on chromosome 9q34.3, is the pore-forming α1B subunit of the neuronal N-type (Cav2.2) high-voltage-activated calcium channel; it assembles with auxiliary α2δ, β and δ subunits to form channels that open in response to strong membrane depolarization, allowing Ca²⁺ influx concentrated at presynaptic active zones where it couples action potentials to asynchronous neurotransmitter release, regulates synaptic plasticity, nociception and neuronal survival, and whose expression is highest in early postnatal life; pathogenic CACNA1B variants producing loss-of-function or altered gating are linked to developmental and epileptic encephalopathy, dystonia, migraine and altered opioid responsiveness, while whole-gene deletion in mice causes memory deficits and abnormal locomotion, illustrating its essential role in central synaptic transmission and neuronal excitability.