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宿主来源
Mouse抗原名称
RORγt分子别名
Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma; NR1F3; RORG; RZRG; RORC细胞定位
NucleusAccession
P51449克隆号
S-4205抗体类型
Mouse mAb抗体同种型
IgG2b,k反应种属 ?
Hu, Ms, Rt阳性样本
mouse thymus, rat thymus纯化方式
Protein A浓度
1 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
应用
WB
稀释度
应用 稀释度 推荐种属 WB 1:1000 Hu, Ms, Rt
RORγt is a DNA-binding transcription factor of the nuclear-receptor superfamily that serves as the master lineage-defining factor for Th17 cells, ILC3s, and other IL-17-producing lymphocytes, where it integrates cholesterol-derived oxysterol signals to drive the transcription of IL-17A/F, IL-22, and related pro-inflammatory genes, thereby orchestrating mucosal host defense against extracellular bacteria and fungi while also controlling circadian gene networks, lymphoid-organ development, and Treg/Th17 balance, making its activity—tunable by small-molecule agonists or inverse agonists—a pivotal rheostat in autoimmune, neoplastic, and infectious disease pathogenesis.
免疫印迹
WB result of RORγt Recombinant Mouse mAb
Primary antibody: RORγt Recombinant Mouse mAb at 1/1000 dilution
Lane 1: mouse spleen lysate 20 µg
Lane 2: mouse thymus lysate 20 µg
Negative control: mouse spleen lysate
Secondary antibody: Goat Anti- mouse IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 58 kDa
Observed MW: 56 kDaWB result of RORγt Recombinant Mouse mAb
Primary antibody: RORγt Recombinant Mouse mAb at 1/1000 dilution
Lane 1: rat spleen lysate 20 µg
Lane 2: rat thymus lysate 20 µg
Negative control: rat spleen lysate
Secondary antibody: Goat Anti- mouse IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 58 kDa
Observed MW: 56 kDa
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