PSAT1 Recombinant Rabbit mAb (S-3054-5)

PSAT1 (phosphoserine aminotransferase 1) is a pyridoxal-5′-phosphate-dependent enzyme that catalyzes the reversible conversion of 3-phosphohydroxypyruvate and glutamate into 3-phosphoserine and α-ketoglutarate, representing the second step in the de novo L-serine biosynthesis pathway that fuels one-carbon metabolism, nucleotide and phospholipid production, and cellular redox balance; highly expressed in liver, brain and proliferating tissues, PSAT1 is frequently up-regulated in multiple cancers where its increased activity supports tumor growth, metastasis and chemoresistance by maintaining serine/glycine homeostasis and NADPH generation through mitochondrial and cytosolic isoforms, while inherited mutations in PSAT1 cause Neu-Laxova syndrome, a severe congenital disorder characterized by microcephaly, ichthyosis and lethality, underscoring its essential role in both normal development and disease.