FOXA1 Recombinant Rabbit mAb (S-4339)

FOXA1, a 46-kDa, 472-aa winged-helix/forkhead DNA-binding pioneer transcription factor, opens compacted chromatin by partial nucleosome unfolding, thereby enabling recruitment of steroid-hormone receptors and lineage-specific transcriptional programs that govern development, differentiation, and adult homeostasis of liver, pancreas, lung, prostate, and breast; in cancer it acts as a context-dependent tumor suppressor or oncogene—most notably driving estrogen-receptor-α (ERα) binding and luminal breast/prostate identity—through genomic rearrangements, hotspot mutations (e.g., R219S/W), or altered protein–protein interactions that reprogram enhancer landscapes, control epithelial–mesenchymal plasticity, and modulate therapeutic response to endocrine agents, making FOXA1 a critical determinant of lineage fidelity, drug sensitivity, and patient prognosis.