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PARP Recombinant Rabbit mAb (S-4303) STAR

Poly [ADP-ribose] polymerase 1,PARP-1,ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1),DNA ADP-ribosyltransferase PARP1,NAD(+) ADP-ribosyltransferase 1 (ADPRT 1),Poly[ADP-ribose] synthase 1,Protein poly-ADP-ribosyltransferase PARP1,ADPRT,PPOL,PARP1

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B6645
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    PARP

  • 分子别名

    Poly [ADP-ribose] polymerase 1; PARP-1; ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1); DNA ADP-ribosyltransferase PARP1; NAD(+) ADP-ribosyltransferase 1 (ADPRT 1); Poly[ADP-ribose] synthase 1; Protein poly-ADP-ribosyltransferase PARP1; ADPRT; PPOL; PARP1

  • 细胞定位

    Cytoplasm, Nucleus

  • Accession

    P09874

  • 克隆号

    S-4303

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Hu, Ms

  • 阳性样本

    HEK-293, SW620, Etoposide treated Jurkat

  • 纯化方式

    Protein A

  • 浓度

    0.5 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

  • 应用

    WB

  • 稀释度

    应用 稀释度 推荐种属
    WB 1:1000 Hu, Ms
背景介绍

  • PARP (poly(ADP-ribose) polymerase) is a family of nuclear enzymes that detect and signal DNA strand breaks, catalyzing the transfer of ADP-ribose units from NAD⁺ to target proteins to create poly(ADP-ribose) chains that recruit DNA repair factors, thereby playing a central role in base-excision and single-strand break repair; pharmacological inhibition of PARP1/2 is synthetically lethal in BRCA1/2-mutated tumors because it traps the enzyme on DNA, preventing repair of replication-associated double-strand breaks that cannot be accurately rejoined in homologous-recombination–deficient cells, a strategy that underlies several approved cancer therapies.

  • 免疫印迹

    • WB result of PARP Recombinant Rabbit mAb
      Primary antibody: PARP Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: HEK-293 whole cell lysate 20 µg
      Lane 2: SW620 whole cell lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 113 kDa
      Observed MW: 120 kDa

    • WB result of PARP Recombinant Rabbit mAb
      Primary antibody: PARP Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: untreated Jurkat whole cell lysate 20 µg
      Lane 2: Jurkat treated with 25 µM Etoposide for 5 hours whole cell lysate 20 µg
      Secondary antibody: Goat Anti- rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 113 kDa
      Observed MW: 120, 90 kDa

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