MAP3K1 Recombinant Rabbit mAb (S-3097-61)

Mitogen-activated protein kinase kinase kinase 1,MAPK/ERK kinase kinase 1 (MEK kinase 1,MEKK 1),MAPKKK1,MEKK,MEKK1

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B6589

规格

25μl100μl1ml

数量

产品介绍

产品介绍评论(0)

产品规格

宿主来源

Rabbit
抗原名称

MAP3K1
分子别名

Mitogen-activated protein kinase kinase kinase 1; MAPK/ERK kinase kinase 1 (MEK kinase 1; MEKK 1); MAPKKK1; MEKK; MEKK1
免疫原

Synthetic Peptide
细胞定位

Cytoplasm
Accession

Q13233
克隆号

S-3097-61
抗体类型

Recombinant mAb
抗体同种型

IgG
反应种属 ?

Hu, Ms, Rt, Mk
阳性样本

293T, SH-SY5Y, A431, A549, EL4, NIH/3T3, mouse testis, mouse embryo, rat testis, COS-7
纯化方式

Protein A
浓度

0.5 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

WB
稀释度

应用稀释度推荐种属

WB 1:1000 Hu, Ms, Rt, Mk

应用	稀释度	推荐种属
WB	1:1000	Hu, Ms, Rt, Mk

背景介绍

MAP3K1 (MEKK1) is a 196-kDa serine/threonine kinase that sits at the hub of multiple signaling cascades: it functions as the apical MAP3K in the classical ERK5 and JNK pathways, phosphorylating and activating MKK5 and MKK4/7 respectively, while also cross-talking to the canonical NF-κB axis by catalyzing IKKβ phosphorylation; beyond kinase activity it acts as a ubiquitin E3 ligase that targets downstream adaptors such as TRAF2 and DUSP1 for degradation, thereby fine-tuning stress, cytokine and receptor-tyrosine-kinase responses; gain-of-function missense mutations clustered in its N-terminal PH domain and C-terminal kinase domain are among the most frequent genomic events in estrogen-receptor-positive breast and endometrial cancers, where they enhance transcription of ER-dependent proliferative genes, drive anti-apoptotic signaling and confer resistance to endocrine therapies, making MAP3K1 both a key integrator of cellular stress decisions and an actionable driver of luminal-type women’s cancers.